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Article

Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

van Es Johan H, Clevers Hans

Abstract excerpt

Genetically engineered mouse models of intestinal cancer are experimental systems in which mice are genetically manipulated to develop malignancies in the gastrointestinal tract. These models enable researchers to study the mechanisms of onset, progression, and metastasis of the disease. They also provide a valuable biological system which is suitable for testing (novel) drugs in vivo. Recently, an in vitro...

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Identifiers

PMID: 25636467
DOI: 10.1007/978-1-4939-2297-0_6

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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