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Article

Influence of UGT1A1 polymorphisms on the outcome of acute myeloid leukemia patients treated with cytarabine-base regimens.

Journal of translational medicine - 17 Jul 2018

Chen Peng, Zhu Ke-Wei, Zhang Dao-Yu, Yan Han, Liu Han, Liu Yan-Ling, Cao Shan, Zhou Gan, Zeng Hui, Chen Shu-Ping, Zhao Xie-Lan, Yang Jing, Chen Xiao-Ping

Abstract excerpt

BACKGROUNDS: UDP-glucuronosyltransferase 1A subfamily (UGT1A) enzymes can inactivate cytarabine (Ara-C) by glucuronidation, and thus serves as candidate genes for interindividual difference in Ara-C response. UGT1A1 is a major UGT1A isoform expressed in human liver. METHODS: UGT1A1*6 and *28 polymorphisms resulting in reduced UGT1A1 activity were genotyped in 726 adult acute myeloid leukemia (AML) patients...

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Identifiers

PMID: 30016963
DOI: 10.1186/s12967-018-1579-3
PMCID: PMC6050722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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