UGT1A1 genotype influences clinical outcome in patients with intermediate-risk acute myeloid leukemia treated with cytarabine-based chemotherapy.

doi:10.1038/s41375-020-0784-2

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UGT1A1 genotype influences clinical outcome in patients with intermediate-risk acute myeloid leukemia treated with cytarabine-based chemotherapy.

Leukemia - 1 Nov 2020

Díaz-Santa Johana, Rodríguez-Romanos Rocío, Osca Gemma, Pratcorona Marta, Garrido Ana, Coll Rosa, Moret Carla, Escoda Lourdes, Tormo Mar, Heras Inma, Arnan Montse, Vives Susanna, Salamero Olga, Lloveras Natàlia, Bargay Joan, Sampol Antònia, Cruz David, Garcia Antoni, Quiñones Teresa, Esteve Jordi, Sierra Jorge, Gallardo David

Abstract excerpt

The treatment of acute myeloid leukemia (AML) is adjusted according to cytogenetic risk factors and molecular markers. Cytarabine remains the main drug to treat AML, and several studies have explored the prognostic relevance of the genotype of cytarabine metabolizing enzymes in AML. Glucuronidation has been identified to be relevant in the cytarabine clearance, but there are still few data concerning the clinical...

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PMID: 32152464
DOI: 10.1038/s41375-020-0784-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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