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Correlation between UGT1A1 polymorphism and efficacy and toxicity of irinotecan in Chinese cancer patients

18 Mar 2025

Abstract excerpt

Objective: To assess the association between UGT1A1*6/*28 polymorphisms and Irinotecan (IRI) efficacy/toxicity in Chinese cancer patients. Method: We systematically searched PubMed, Cochrane, CNKI, and Wanfang databases. Two investigators independently conducted literature screening, data extraction, and meta-analysis using Revman 5.4. Results: This study included 19 clinical trials or case-control studies, with...

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PMID: 40170723
DOI: 10.3389/fphar.2025.1563566

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