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Clonal immunoglobulin λ light‐chain gene rearrangements detected by next generation sequencing in POEMS syndrome

17 Jul 2018

Abstract excerpt

Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare plasma cell dyscrasia characterized by polyneuropathy, organomegaly, endocrinopathy, extravascular fluid overload, M protein, and a myriad of skin changes. The pathogenesis is poorly understood, but monoclonal plasma cells are λ-restricted and these immunoglobulin λ light chain variable (IGLV) region genes are...

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PMID: 30015379
DOI: 10.1002/ajh.25213

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