Asymmetrical 5’RACE RNA-based immunoglobulins repertoire sequencing is an accurate and specific tool for diagnosis of POEMS syndrome

Abstract excerpt

<h4>ABSTRACT</h4> POEMS syndrome is a rare form of plasma cell dyscrasia with multiple clinical features including polyneuropathy and sclerotic bone lesions. As various signs and symptoms can be observed, diagnosis is often delayed and we need an accurate diagnosis tool for these patients. Vascular endothelial growth factor (VEGF) is known to play a major role in the pathology and is frequently increased in sera o...

Topics

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• Autoimmune Bullous Skin Diseases
• Combined Modality Therapy
• Diagnosis, Differential
• Hereditary Neurological Disorders
• Peripheral Neuropathies and Disorders
• Phenotype
• Platelet Disorders and Treatments
• Prognosis

Identifiers and source

Literature Corpus work

96a0799b-a798-5839-a771-41cc5cbbe34f

DOI

10.1101/2024.11.15.24316857