Article

Full-length immunoglobulin high-throughput sequencing reveals specific novel mutational patterns in POEMS syndrome

2019-10-31

Abstract excerpt

POEMS syndrome is a rare multisystem disease due to an underlying plasma cell (PC) dyscrasia. The pathophysiology of the disease remains unclear but the role of the monoclonal immunoglobulin (Ig) light chain (LC) is strongly suspected, due to the highly restrictive usage of two λ variable (V) domains (IGLV1-40 and IGLV1-44) and the general improvement of clinical manifestations following PC clone-targeted treatmen...

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Literature Corpus work: 40600c88-d957-5df2-99d6-7643c97e073e
DOI: 10.1101/824722

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