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Immunoglobulin variable domain high-throughput sequencing reveals specific novel mutational patterns in POEMS syndrome

3 Apr 2020

Abstract excerpt

Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystem disease resulting from an underlying plasma cell (PC) dyscrasia. The pathophysiology of the disease remains unclear, but the role of the monoclonal immunoglobulin (Ig) light chain (LC) is strongly suspected because of the highly restrictive usage of 2 λ variable (V) domains (IGLV1-40 and...

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PMID: 32243509
DOI: 10.1182/blood.2019004197

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