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Article

A highly heterogeneous mutational pattern in POEMS syndrome.

Leukemia - 1 Apr 2021

Chen Jia, Gao Xue-Min, Zhao Hao, Cai Hao, Zhang Lu, Cao Xin-Xin, Zhou Dao-Bin, Li Jian

Abstract excerpt

POEMS syndrome is a rare plasma cell dyscrasia. Little is known about its pathogenesis and genetic features. We analyzed the mutational features of purified bone marrow plasma cells from 42 patients newly diagnosed with POEMS syndrome using a two-step strategy. Whole exome sequencing of ten patients showed a total of 170 somatic mutations in exonic regions and splicing sites, with paired peripheral blood...

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Identifiers

PMID: 33262528
DOI: 10.1038/s41375-020-01101-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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