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ZNF830 mediates cancer chemoresistance through promoting homologous-recombination repair

6 Dec 2017

Abstract excerpt

Homologous recombination (HR), which mediates the repair of DNA double-strand breaks (DSB), is crucial for maintaining genomic integrity and enhancing survival in response to chemotherapy and radiotherapy in human cancers. However, the mechanisms of HR repair in treatment resistance for the improvement of cancer therapy remains unclear. Here, we report that the zinc finger protein 830 (ZNF830) promotes HR repair...

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PMID: 29244158
DOI: 10.1093/nar/gkx1258

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