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Article

The Cytochrome P450 Slow Metabolizers CYP2C92 and CYP2C93 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.

Cancer research - 1 Sept 2018

Sausville Lindsay N, Gangadhariah Mahesha H, Chiusa Manuel, Mei Shaojun, Wei Shouzuo, Zent Roy, Luther James M, Shuey Megan M, Capdevila Jorge H, Falck John R, Guengerich F Peter, Williams Scott M, Pozzi Ambra

Abstract excerpt

Increased expression of cytochrome P450 CYP2C9, together with elevated levels of its products epoxyeicosatrienoic acids (EET), is associated with aggressiveness in cancer. Cytochrome P450 variants CYP2C9*2 and CYP2C9*3 encode proteins with reduced enzymatic activity, and individuals carrying these variants metabolize drugs more slowly than individuals with wild-type CYP2C9*1, potentially affecting their response...

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Identifiers

PMID: 30012669
DOI: 10.1158/0008-5472.CAN-17-3977
PMCID: PMC6125168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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