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Cytochrome P450 1B1 and 2C9 genotypes and risk of ischemic vascular disease, cancer, and chronic obstructive pulmonary disease.

Current vascular pharmacology - 1 Jul 2012

Kaur-Knudsen Diljit, Bojesen Stig E, Nordestgaard Børge G

Abstract excerpt

The aim of this review is to summarize present knowledge of genetic variation in cytochrome P450 1B1 (CYP1B1) and 2C9 (CYP2C9) genes and risk of tobacco-related cancer, female cancer, chronic obstructive pulmonary disease and ischemic vascular disease. The CYP1B1 and CYP2C9 enzymes metabolize polycyclic aromatic hydrocarbons found in tobacco smoke and thereby generate disease-causing metabolites suggested to be...

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PMID: 22272893
DOI: 10.2174/157016112800812746

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