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Article

Interaction between smoking and CYP2C19*3 polymorphism increased risk of lung cancer in a Chinese population.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jun 2014

Yan Fei, Xu Jin-Fu, Liu Xiao-fang, Li Xing-Hua

Abstract excerpt

Cytochrome P450 (CYP) 2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which play a crucial role in either the detoxification or inactivation of potential carcinogens, or the bioactivation of some environmental procarcinogens to reactive DNA-binding metabolites. And smoking is a major risk factor for lung cancer. The purpose of...

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Source

Identifiers

PMID: 24510350
DOI: 10.1007/s13277-014-1689-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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