Article
Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2.
PloS one - 1 Jan 2012
Chen Fuqiong, Chen Chen, Yang Shenglan, Gong Wei, Wang Yan, Cianflone Katherine, Tang Jiarong, Wang Dao Wen
Abstract excerpt
BACKGROUND: MicroRNAs (miRNAs) are small, noncoding RNA molecules of 20 to 22 nucleotides that regulate gene expression by binding to their 3' untranslated region (3'UTR). Increasing data implicate altered miRNA participation in the progress of cancer. We previously reported that CYP2J2 epoxygenase promotes human cancer phenotypes. But whether and how CYP2J2 is regulated by miRNA is not understood. METHODS AND...
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