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Article

Microarray Glycoprofiling of CA125 Improves Differential Diagnosis of Ovarian Cancer

29 Jan 2013

Abstract excerpt

The CA125 biomarker assay plays an important role in the diagnosis and management of primary invasive epithelial ovarian/tubal cancer (iEOC). However, a fundamental problem with CA125 is that it is not cancer-specific and may be elevated in benign gynecological conditions such as benign ovarian neoplasms and endometriosis. Aberrant O-glycosylation is an inherent and specific property of cancer cells and could...

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PMID: 23360124
DOI: 10.1021/pr3010474

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