Article
Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype.
Cellular and molecular life sciences : CMLS - 1 Jan 2021
Madunić Katarina, Zhang Tao, Mayboroda Oleg A, Holst Stephanie, Stavenhagen Kathrin, Jin Chunsheng, Karlsson Niclas G, Lageveen-Kammeijer Guinevere S M, Wuhrer Manfred
Abstract excerpt
Alterations in protein glycosylation in colorectal cancer (CRC) have been extensively studied using cell lines as models. However, little is known about their O-glycome and the differences in glycan biosynthesis in different cell types. To provide a better understanding of the variation in O-glycosylation phenotypes and their association with other molecular features, an in-depth O-glycosylation analysis of 26...
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