Article
Inference of epistatic effects in a key mitochondrial protein.
Physical review. E - 1 Jun 2018
Nelson Erik D, Grishin Nick V
Abstract excerpt
We use Potts model inference to predict pair epistatic effects in a key mitochondrial protein-cytochrome c oxidase subunit 2-for ray-finned fishes. We examine the effect of phylogenetic correlations on our predictions using a simple exact fitness model, and we find that, although epistatic effects are underpredicted, they maintain a roughly linear relationship to their true (model) values. After accounting for...
Topics
- Animals
- Cell Lineage
- Epistasis, Genetic
- Evolution, Molecular
- Fish Proteins
- Fishes
- Genetic Fitness
- Mitochondrial Proteins
- Models, Genetic
- Models, Molecular
- Mutation