Article
Robustness of phylogenetic inference to model misspecification caused by pairwise epistasis
2020-11-17
Abstract excerpt
Likelihood-based phylogenetic inference posits a probabilistic model of character state change along branches of a phylogenetic tree. These models typically assume statistical independence of sites in the sequence alignment. This is a restrictive assumption that facilitates computational tractability, but ignores how epistasis, the effect of genetic background on mutational effects, influences the evolution of fun...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- c858c28d-9f9c-5c2c-b37a-9cc6533a261d
- DOI
- 10.1101/2020.11.17.387365