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Article

MyD88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice.

Human molecular genetics - 1 Oct 2018

Gallot Yann S, Straughn Alex R, Bohnert Kyle R, Xiong Guangyan, Hindi Sajedah M, Kumar Ashok

Abstract excerpt

Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, leads to severe muscle wasting and eventual death of the afflicted individuals, primarily due to respiratory failure. Deficit in myofiber regeneration, potentially due to an exhaustion of satellite cells, is one of the major pathological features of DMD. Myeloid differentiation primary response 88 (MyD88) is an adaptor protein that...

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Share to Dystrophin
Share to Mice, Inbred mdx
Share to Muscular Dystrophy, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Dystrophy, Duchenne

Share to Myeloid Differentiation Factor 88

Share to Myofibrils

Share to Regeneration

Share to Satellite Cells, Skeletal Muscle

Source

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Identifiers

PMID: 30010933
DOI: 10.1093/hmg/ddy258
PMCID: PMC6140782

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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