Article
Role of Toll-like receptors in the pathogenesis of dystrophin-deficient skeletal and heart muscle.
Human molecular genetics - 15 May 2014
Henriques-Pons Andrea, Yu Qing, Rayavarapu Sree, Cohen Tatiana V, Ampong Beryl, Cha Hee Jae, Jahnke Vanessa, Van der Meulen Jack, Wang Daqing, Jiang Weiwen, Kandimalla Ekambar R, Agrawal Sudhir, Spurney Chistopher F, Nagaraju Kanneboyina
Abstract excerpt
Although the cause of Duchenne muscular dystrophy (DMD) is known, the specific factors that initiate and perpetuate disease progression are not well understood. We hypothesized that leaky dystrophin-deficient skeletal muscle releases endogenous danger signals (TLR ligands), which bind to Toll-like receptors (TLRs) on muscle and immune cells and activate downstream processes that facilitate degeneration and...
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