Article
Muscle regeneration in dystrophin-deficient mdx mice studied by gene expression profiling.
BMC genomics - 13 Jul 2005
Turk R, Sterrenburg E, de Meijer E J, van Ommen G-J B, den Dunnen J T, 't Hoen P A C
Abstract excerpt
BACKGROUND: Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is lethal. In contrast, dystrophin-deficient mdx mice recover due to effective regeneration of affected muscle tissue. To characterize the molecular processes associated with regeneration, we compared gene expression levels in hindlimb muscle tissue of mdx and control mice at 9 timepoints, ranging from 1-20 weeks of age....
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