Article
Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy
1 Jan 2014
Abstract excerpt
Duchenne muscular dystrophy (DMD) is a devastating disease characterized by muscle wasting, loss of mobility and death in early adulthood. Satellite cells are muscle-resident stem cells responsible for the repair and regeneration of damaged muscles. One pathological feature of DMD is the progressive depletion of satellite cells, leading to the failure of muscle repair. Here, we attempted to explore the molecular...
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