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Article

Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype.

Human molecular genetics - 15 Feb 2011

Villalta S Armando, Rinaldi Chiara, Deng Bo, Liu Grace, Fedor Brian, Tidball James G

Abstract excerpt

M1 macrophages play a major role in worsening muscle injury in the mdx mouse model of Duchenne muscular dystrophy. However, mdx muscle also contains M2c macrophages that can promote tissue repair, indicating that factors regulating the balance between M1 and M2c phenotypes could influence the severity of the disease. Because interleukin-10 (IL-10) modulates macrophage activation in vitro and its expression is...

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Identifiers

PMID: 21118895
DOI: 10.1093/hmg/ddq523
PMCID: PMC3024048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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