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Article

Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice.

Human molecular genetics - 1 Nov 2015

Pelosi Laura, Berardinelli Maria Grazia, Forcina Laura, Spelta Elisa, Rizzuto Emanuele, Nicoletti Carmine, Camilli Carlotta, Testa Erika, Catizone Angela, De Benedetti Fabrizio, Musarò Antonio

Abstract excerpt

Duchenne muscular dystrophy (DMD) is characterized by progressive lethal muscle degeneration and chronic inflammatory response. The mdx mouse strain has served as the animal model for human DMD. However, while DMD patients undergo extensive necrosis, the affected muscles of adult mdx mice rapidly regenerates and regains structural and functional integrity. The basis for the mild effects observed in mice compared...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26251044
DOI: 10.1093/hmg/ddv323
PMCID: PMC4599671

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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