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Article

Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses.

Journal of leukocyte biology - 1 Jun 2009

Taylor Simon R J, Gonzalez-Begne Mireya, Sojka Dorothy K, Richardson Jill C, Sheardown Steven A, Harrison Stephen M, Pusey Charles D, Tam Frederick W K, Elliott James I

Abstract excerpt

The purinergic receptor P2X(7) is expressed on immune cells, and its stimulation results in the release of IL-1beta from macrophages. Its absence, as evidenced from the analysis of two independent strains of P2X(7)-deficient mice, results in reduced susceptibility to inflammatory disease, and the molecule is an important, potential therapeutic target in autoimmunity. However, P2X(7) has also been detected in...

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Identifiers

PMID: 19276178
DOI: 10.1189/jlb.0408251
PMCID: PMC2698584

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Source receipt: pubmed, retrieved 7 Sept 2026.

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