Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses.

Journal of leukocyte biology - 1 Jun 2009

Taylor Simon R J, Gonzalez-Begne Mireya, Sojka Dorothy K, Richardson Jill C, Sheardown Steven A, Harrison Stephen M, Pusey Charles D, Tam Frederick W K, Elliott James I

Abstract excerpt

The purinergic receptor P2X(7) is expressed on immune cells, and its stimulation results in the release of IL-1beta from macrophages. Its absence, as evidenced from the analysis of two independent strains of P2X(7)-deficient mice, results in reduced susceptibility to inflammatory disease, and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Galactosidase
Share to CD4-Positive T-Lymphocytes
Share to Dendritic Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Lymphocytes

Share to Receptors, Purinergic P2

Share to Receptors, Purinergic P2X7

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 19276178
DOI: 10.1189/jlb.0408251
PMCID: PMC2698584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19276178-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses.PMID 19276178Read ↗

Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes.Semantic proximity Read ↗

Regulation of Immune Response by P2X7 ReceptorSemantic proximity Read ↗

Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system—No evidence for the role of neuronal P2X7 receptors in colitisSemantic proximity Read ↗

Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobodySemantic proximity Read ↗

A Glu-496 to Ala Polymorphism Leads to Loss of Function of the Human P2X7 ReceptorSemantic proximity Read ↗

P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of TauopathySemantic proximity Read ↗

Major histocompatibility complex class I shedding and programmed cell death stimulated through the proinflammatory P2X7 receptor: a candidate susceptibility gene for NOD diabetes.Semantic proximity Read ↗

Expression and function of the P2X(7) purinergic receptor in patients with systemic lupus erythematosus and rheumatoid arthritis.Semantic proximity Read ↗

The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products.Semantic proximity Read ↗

PIP(2) regulates the ionic current of P2X receptors and P2X(7) receptor-mediated cell death.Semantic proximity Read ↗

Functional Expression of the P2X7 ATP Receptor Requires Eros.Semantic proximity Read ↗

Trophic activity of a naturally occurring truncated isoform of the P2X7 receptorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.