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Article

Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death

25 May 2016

Abstract excerpt

Lymphocyte growth and differentiation are modulated by extracellular nucleotides and P2 receptors. We previously showed that the P2X7 receptor (P2X7R or P2RX7) is overexpressed in circulating lymphocytes from chronic lymphocytic leukemia (CLL) patients. In the present study we investigated the P2X7R/NLRP3 inflammasome axis in lymphocytes from a cohort of 23 CLL patients. P2X7R, ASC and NLRP3 were investigated by...

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PMID: 27221966
DOI: 10.1038/srep26280

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