Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.

doi:10.1001/jamapsychiatry.2017.2269

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.

JAMA psychiatry - 1 Nov 2017

Andersen Allan M, Pietrzak Robert H, Kranzler Henry R, Ma Li, Zhou Hang, Liu Xiaoming, Kramer John, Kuperman Samuel, Edenberg Howard J, Nurnberger John I, Rice John P, Tischfield Jay A, Goate Alison, Foroud Tatiana M, Meyers Jacquelyn L, Porjesz Bernice, Dick Danielle M, Hesselbrock Victor, Boerwinkle Eric, Southwick Steven M, Krystal John H, Weissman Myrna M, Levinson Douglas F, Potash James B, Gelernter Joel, Han Shizhong

Abstract excerpt

Importance: Major depressive disorder (MDD) and alcohol dependence (AD) are heritable disorders with significant public health burdens, and they are frequently comorbid. Common genetic factors that influence the co-occurrence of MDD and AD have been sought in family, twin, and adoption studies, and results to date have been promising but inconclusive. Objective: To examine whether AD and MDD overlap genetically,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comorbidity

Share to Depressive Disorder, Major

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to United States

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 28813562
DOI: 10.1001/jamapsychiatry.2017.2269
PMCID: PMC5710224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.PMID 28813562Read ↗

Shared genetic etiology between alcohol dependence and major depressive disorder.Semantic proximity Read ↗

The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder.Semantic proximity Read ↗

Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.Semantic proximity Read ↗

Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortiumSemantic proximity Read ↗

Shared additive genetic influences on DSM-IV criteria for alcohol dependence in subjects of European ancestry.Semantic proximity Read ↗

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.Semantic proximity Read ↗

Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samplesSemantic proximity Read ↗

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and medical traitsSemantic proximity Read ↗

Genome-wide association study of comorbid depressive syndrome and alcohol dependence.Semantic proximity Read ↗

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics ConsortiumSemantic proximity Read ↗

Toward Clinical Implementation of Polygenic Scores for Substance Use Disorders: A Multi-Ancestry StudySemantic proximity Read ↗

Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.