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Article

Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.

JAMA psychiatry - 1 Dec 2017

Zhou Hang, Polimanti Renato, Yang Bao-Zhu, Wang Qian, Han Shizhong, Sherva Richard, Nuñez Yaira Z, Zhao Hongyu, Farrer Lindsay A, Kranzler Henry R, Gelernter Joel

Abstract excerpt

Importance: Alcohol dependence (AD) and major depression (MD) are leading causes of disability that often co-occur. Genetic epidemiologic data have shown that AD and MD share a common possible genetic cause. The molecular nature of this shared genetic basis is poorly understood. Objectives: To detect genetic risk variants for comorbid AD and MD and to determine whether polygenic risk alleles are shared with...

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Identifiers

PMID: 29071344
DOI: 10.1001/jamapsychiatry.2017.3275
PMCID: PMC6331050

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