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Article

DRD2promoter methylation and measures of alcohol reward: functional activation of reward circuits and clinical severity

21 Feb 2018

Abstract excerpt

Studies have identified strong associations between D2 receptor binding potential and neural responses to rewarding stimuli and substance use. Thus, D2 receptor perturbations are central to theoretical models of the pathophysiology of substance dependence, and epigenetic changes may represent one of the fundamental molecular mechanisms impacting the effects of alcohol exposure on the brain. We hypothesized that...

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PMID: 29464814
DOI: 10.1111/adb.12614

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