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Article

A hierarchical Bayesian model to predict APOE4 genotype and the age of Alzheimer's disease onset.

PloS one - 1 Jan 2018

Hane Francis, Augusta Carolyn, Bai Owen

Abstract excerpt

In this work we use a hierarchical Bayesian paradigm to introduce a theoretical framework to determine an individual's Apolipoprotein ε4 (APOE4) genotype, which heavily influences both the age of onset and probability of acquiring Alzheimer's disease (AD). This calculation is based solely on an individual's family history. This APOE4 genotype estimation is then combined with a number of known factors that...

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Identifiers

PMID: 30001420
DOI: 10.1371/journal.pone.0200263
PMCID: PMC6042730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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