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Article

Analyzing the effect of APOE on Alzheimer's disease progression using an event-based model for stratified populations.

NeuroImage - 15 Feb 2021

Venkatraghavan Vikram, Klein Stefan, Fani Lana, Ham Leontine S, Vrooman Henri, Ikram M Kamran, Niessen Wiro J, Bron Esther E

Abstract excerpt

Alzheimer's disease (AD) is the most common form of dementia and is phenotypically heterogeneous. APOE is a triallelic gene which correlates with phenotypic heterogeneity in AD. In this work, we determined the effect of APOE alleles on the disease progression timeline of AD using a discriminative event-based model (DEBM). Since DEBM is a data-driven model, stratification into smaller disease subgroups would lead...

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PMID: 33338617
DOI: 10.1016/j.neuroimage.2020.117646

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