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Article

Conditional Astroglial Rictor Overexpression Induces Malignant Glioma in Mice

15 Oct 2012

Abstract excerpt

BACKGROUND: Hyperactivation of the mTORC2 signaling pathway has been shown to contribute to the oncogenic properties of gliomas. Moreover, overexpression of the mTORC2 regulatory subunit Rictor has been associated with increased proliferation and invasive character of these tumor cells. METHODOLOGY/PRINCIPAL FINDINGS: To determine whether Rictor overexpression was sufficient to induce glioma formation in mice, we...

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PMID: 23077666
DOI: 10.1371/journal.pone.0047741

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