Article
Stepwise Tikhonov Regularisation: Application to the Prediction of HIV-1 Drug Resistance.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Delgado Ramon A, Chen Zhiyong, Middleton Richard H
Abstract excerpt
This paper focuses on constructing genotypic predictors for antiretroviral drug susceptibility of HIV. To this end, a method to recover the largest elements of an unknown vector in a least squares problem is developed. The proposed method introduces two novel ideas. The first idea is a novel forward stepwise selection procedure based on the magnitude of the estimates of the candidate variables. To implement this...
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