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Article

Identification of drug resistance mutations in HIV from constraints on natural evolution.

Physical review. E - 1 Feb 2016

Butler Thomas C, Barton John P, Kardar Mehran, Chakraborty Arup K

Abstract excerpt

Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape. Here we show that an Ising model describing these interactions, inferred from sequence data obtained prior to the use of antiretroviral drugs, can be used to identify clinically significant sites of resistance mutations. Successful predictions of...

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Identifiers

PMID: 26986367
DOI: 10.1103/PhysRevE.93.022412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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