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Article

Biomarker discovery using targeted maximum-likelihood estimation: application to the treatment of antiretroviral-resistant HIV infection.

Statistics in medicine - 15 Jan 2009

Bembom Oliver, Petersen Maya L, Rhee Soo-Yon, Fessel W Jeffrey, Sinisi Sandra E, Shafer Robert W, van der Laan Mark J

Abstract excerpt

Researchers in clinical science and bioinformatics frequently aim to learn which of a set of candidate biomarkers is important in determining a given outcome, and to rank the contributions of the candidates accordingly. This article introduces a new approach to research questions of this type, based on targeted maximum-likelihood estimation of variable importance measures.The methodology is illustrated using an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18825650
DOI: 10.1002/sim.3414
PMCID: PMC4107931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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