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Article

A complex syndrome of left-right axis, central nervous system and axial skeleton defects in Zic3 mutant mice.

Development (Cambridge, England) - 1 May 2002

Purandare Smita M, Ware Stephanie M, Kwan Kin Ming, Gebbia Marinella, Bassi Maria Teresa, Deng Jian Min, Vogel Hannes, Behringer Richard R, Belmont John W, Casey Brett

Abstract excerpt

X-linked heterotaxy (HTX1) is a rare developmental disorder characterized by disturbances in embryonic laterality and other midline developmental field defects. HTX1 results from mutations in ZIC3, a member of the GLI transcription factor superfamily. A targeted deletion of the murine Zic3 locus has been created to investigate its function and interactions with other molecular components of the left-right axis...

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Source

Identifiers

PMID: 11959836
DOI: 10.1242/dev.129.9.2293

Genes

ZIC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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