Article
Association of IL17 and IL23R gene polymorphisms with rheumatic heart disease in South Indian population.
Immunological investigations - 1 Oct 2018
Poomarimuthu Maheshkumar, Elango Sivakumar, Solomon Pravin Raj, Soundrapandian Sambath, Mariakuttikan Jayalakshmi
Abstract excerpt
BACKGROUND: IL-23/Th17 signaling pathway plays a crucial role in the cell-mediated immune response against bacterial infections and also in the pathogenesis of inflammatory and autoimmune diseases. Recent studies indicate that Th17 cell-associated cytokines are involved in the progression and maintenance of valvular lesions in rheumatic heart disease (RHD). Variants in the genes of cytokines that are potentially...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.