Article
Association of IL17 and IL23R gene polymorphisms with rheumatic heart disease in South Indian population.
Immunological investigations - 1 Oct 2018
Poomarimuthu Maheshkumar, Elango Sivakumar, Solomon Pravin Raj, Soundrapandian Sambath, Mariakuttikan Jayalakshmi
Abstract excerpt
BACKGROUND: IL-23/Th17 signaling pathway plays a crucial role in the cell-mediated immune response against bacterial infections and also in the pathogenesis of inflammatory and autoimmune diseases. Recent studies indicate that Th17 cell-associated cytokines are involved in the progression and maintenance of valvular lesions in rheumatic heart disease (RHD). Variants in the genes of cytokines that are potentially...
Topics
- Adolescent
- Alleles
- Child
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype
- Humans
- India
- Interleukin-17