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Article

The rad51-K191R ATPase-defective mutant is impaired for presynaptic filament formation.

Molecular and cellular biology - 1 Dec 2006

Fung Cindy W, Fortin Gary S, Peterson Shaun E, Symington Lorraine S

Abstract excerpt

The nucleoprotein filament formed by Rad51 polymerization on single-stranded DNA is essential for homologous pairing and strand exchange. ATP binding is required for Rad51 nucleoprotein filament formation and strand exchange, but ATP hydrolysis is not required for these functions in vitro. Previous studies have shown that a yeast strain expressing the rad51-K191R allele is sensitive to ionizing radiation,...

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Identifiers

PMID: 17030607
DOI: 10.1128/MCB.00599-06
PMCID: PMC1698519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The rad51-K191R ATPase-defective mutant is impaired for presynaptic filament formation.PMID 17030607Read ↗

The requirement for ATP hydrolysis by Saccharomyces cerevisiae Rad51 is bypassed by mating-type heterozygosity or RAD54 in high copy.Semantic proximity Read ↗

Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation.Semantic proximity Read ↗

Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.Semantic proximity Read ↗

Rad52 Oligomeric N-Terminal Domain Stabilizes Rad51 Nucleoprotein Filaments and Contributes to Their Protection against Srs2.Semantic proximity Read ↗

Rad51 gain-of-function mutants that exhibit high affinity DNA binding cause DNA damage sensitivity in the absence of Srs2.Semantic proximity Read ↗

Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair.Semantic proximity Read ↗

Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein.Semantic proximity Read ↗

Rad54 protein stimulates heteroduplex DNA formation in the synaptic phase of DNA strand exchange via specific interactions with the presynaptic Rad51 nucleoprotein filament.Semantic proximity Read ↗

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activitySemantic proximity Read ↗

Phosphoregulation of RAD51AP1 function in homology-directed repair.Semantic proximity Read ↗

Rad51 paralog complex Rad55–Rad57 acts as a molecular chaperone during homologous recombinationSemantic proximity Read ↗

RAD-ical New Insights into RAD51 RegulationSemantic proximity Read ↗

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