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Article

GAL3 receptor knockout mice exhibit an alcohol-preferring phenotype.

Addiction biology - 1 Sept 2019

Genders Shannyn G, Scheller Karlene J, Jaehne Emily J, Turner Bradley J, Lawrence Andrew J, Brunner Susanne M, Kofler Barbara, van den Buuse Maarten, Djouma Elvan

Abstract excerpt

Galanin is a neuropeptide which mediates its effects via three G-protein coupled receptors (GAL1-3 ). Administration of a GAL3 antagonist reduces alcohol self-administration in animal models while allelic variation in the GAL3 gene has been associated with an increased risk of alcohol use disorders in diverse human populations. Based on the association of GAL3 with alcoholism, we sought to characterize...

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PMID: 29984872
DOI: 10.1111/adb.12641

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