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Article

Mice expressing a "hyper-sensitive" form of the CB1 cannabinoid receptor (CB1) show modestly enhanced alcohol preference and consumption.

PloS one - 1 Jan 2017

Marcus David J, Henderson-Redmond Angela N, Gonek Maciej, Zee Michael L, Farnsworth Jill C, Amin Randa A, Andrews Mary-Jeanette, Davis Brian J, Mackie Ken, Morgan Daniel J

Abstract excerpt

We recently characterized S426A/S430A mutant mice expressing a desensitization-resistant form of the CB1 receptor. These mice display an enhanced response to endocannabinoids and ∆9-THC. In this study, S426A/S430A mutants were used as a novel model to test whether ethanol consumption, morphine dependence, and reward for these drugs are potentiated in mice with a "hyper-sensitive" form of CB1. Using an...

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Identifiers

PMID: 28426670
DOI: 10.1371/journal.pone.0174826
PMCID: PMC5398885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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