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Article

Melatonin and the pathologies of weakened or dysregulated circadian oscillators.

Journal of pineal research - 1 Jan 2017

Hardeland Rüdiger

Abstract excerpt

Dynamic aspects of melatonin's actions merit increasing future attention. This concerns particularly entirely different effects in senescent, weakened oscillators and in dysregulated oscillators of cancer cells that may be epigenetically blocked. This is especially obvious in the case of sirtuin 1, which is upregulated by melatonin in aged tissues, but strongly downregulated in several cancer cells. These...

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PMID: 27763686
DOI: 10.1111/jpi.12377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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