Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank.

doi:10.2337/db19-0606

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Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank.

Diabetes - 1 Feb 2020

Dashti Hassan S, Vetter Céline, Lane Jacqueline M, Smith Matt C, Wood Andrew R, Weedon Michael N, Rutter Martin K, Garaulet Marta, Scheer Frank A J L, Saxena Richa

Abstract excerpt

Night shift work, behavioral rhythms, and the common MTNR1B risk single nucleotide polymorphism (SNP), rs10830963, associate with type 2 diabetes; however, whether they exert joint effects to exacerbate type 2 diabetes risk is unknown. Among employed participants of European ancestry in the UK Biobank (N = 189,488), we aimed to test the cross-sectional independent associations and joint interaction effects of...

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PMID: 31757795
DOI: 10.2337/db19-0606
PMCID: PMC6971490

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