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Article

Biophysical analysis of sialic acid recognition by the complement regulator Factor H

4 Jul 2018

Abstract excerpt

Complement factor H (FH), an elongated and substantially glycosylated 20-domain protein, is a soluble regulator of the complement alternative pathway (AP). It contains several glycan binding sites which mediate recognition of α2-3-linked sialic acid (FH domain 20) and glycosaminoglycans (domains 6-8 and 19-20). FH also binds the complement C3-activation product C3b, a powerful opsonin and focal point for the...

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PMID: 29982679
DOI: 10.1093/glycob/cwy061

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