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Article

Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen.

Nucleic acids research - 16 Nov 2016

Biondi Elisa, Lane Joshua D, Das Debasis, Dasgupta Saurja, Piccirilli Joseph A, Hoshika Shuichi, Bradley Kevin M, Krantz Bryan A, Benner Steven A

Abstract excerpt

Reported here is a laboratory in vitro evolution (LIVE) experiment based on an artificially expanded genetic information system (AEGIS). This experiment delivers the first example of an AEGIS aptamer that binds to an isolated protein target, the first whose structural contact with its target has been outlined and the first to inhibit biologically important activities of its target, the protective antigen from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27701076
DOI: 10.1093/nar/gkw890
PMCID: PMC5175368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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