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Article

Identifying high-affinity aptamer ligands with defined cross-reactivity using high-throughput guided systematic evolution of ligands by exponential enrichment.

Nucleic acids research - 13 Jul 2015

Levay Agata, Brenneman Randall, Hoinka Jan, Sant David, Cardone Marco, Trinchieri Giorgio, Przytycka Teresa M, Berezhnoy Alexey

Abstract excerpt

Oligonucleotide aptamers represent a novel platform for creating ligands with desired specificity, and they offer many potentially significant advantages over monoclonal antibodies in terms of feasibility, cost, and clinical applicability. However, the isolation of high-affinity aptamer ligands from random oligonucleotide pools has been challenging. Although high-throughput sequencing (HTS) promises to...

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Share to Advanced biosensing and bioanalysis techniques
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26007661
DOI: 10.1093/nar/gkv534
PMCID: PMC4499151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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