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Article

Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery.

Nucleic acids research - 13 Jul 2015

Hoinka Jan, Berezhnoy Alexey, Dao Phuong, Sauna Zuben E, Gilboa Eli, Przytycka Teresa M

Abstract excerpt

High-Throughput (HT) SELEX combines SELEX (Systematic Evolution of Ligands by EXponential Enrichment), a method for aptamer discovery, with massively parallel sequencing technologies. This emerging technology provides data for a global analysis of the selection process and for simultaneous discov...

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Identifiers

PMID: 25870409
DOI: 10.1093/nar/gkv308
PMCID: PMC4499121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25870409-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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