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Article

Activation of invariant NK T cells protects against experimental rheumatoid arthritis by an IL-10-dependent pathway.

European journal of immunology - 1 Dec 2005

Miellot Aurore, Zhu Ren, Diem Séverine, Boissier Marie-Christophe, Herbelin André, Bessis Natacha

Abstract excerpt

Invariant natural killer T (iNKT) cells are a unique lymphocyte subtype implicated in the regulation of autoimmunity and a good source of protective Th2 cytokines. Agonist alpha-galactosylceramide (alpha-GalCer) of iNKT cells exert a therapeutical effect in type 1 diabetes. We investigated whether iNKT activation with alpha-GalCer was protective in collagen-induced arthritis (CIA) in DBA/1 mice, a standard model...

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Identifiers

PMID: 16304639
DOI: 10.1002/eji.200535235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of invariant NK T cells protects against experimental rheumatoid arthritis by an IL-10-dependent pathway.PMID 16304639Read ↗

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Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice.Semantic proximity Read ↗

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Structural and Functional Changes of the Invariant NKT Clonal Repertoire in Early Rheumatoid ArthritisSemantic proximity Read ↗

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NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes.Semantic proximity Read ↗

IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells.Semantic proximity Read ↗

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