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Article

Frequency of Mismatch Repair Protein Deficiency in a Puerto Rican Population with Colonic Adenoma and Adenocarcinoma.

Cancer genomics & proteomics - 1 Jan 2000

Reverón Dayana, López Christian, Gutiérrez Sylvia, Sayegh Zena E, Antonia Teresita, Dutil Julie, Malafa Mokenge, Coppola Domenico

Abstract excerpt

BACKGROUND/AIM: Microsatellite instability (MSI) results from genetic alterations involving the mismatch repair (MMR) genes MLH1, PSM2, MSH2, and MSH6. MSI has been implicated in both sporadic CRC and Lynch syndrome. The aim of the study was to assess the frequency of alterations in MMR protein expression in both primary colorectal cancer and precursor lesions among Puerto Rican patients. PATIENTS AND METHODS: A...

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Source

Open in PubMed Open full text

Identifiers

PMID: 29976631
DOI: 10.21873/cgp.20084
PMCID: PMC6070705

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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