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Article

Clinical characterization and mutation spectrum in Caribbean Hispanic families with Lynch syndrome.

Familial cancer - 1 Sept 2015

Cruz-Correa Marcia, Diaz-Algorri Yaritza, Pérez-Mayoral Julyann, Suleiman-Suleiman Wasilah, Gonzalez-Pons Maria del Mar, Bertrán Carlos, Casellas Nicolás, Rodríguez Natalia, Pardo Sherly, Rivera Keyla, Mosquera Rafael, Rodriguez-Quilichini Segundo

Abstract excerpt

Lynch syndrome (LS) is an inherited form of colorectal cancer (CRC) caused by germline mutations in the mismatch repair (MMR) genes. It accounts for approximately 5% of all CRCs. The prevalence of LS among US Hispanics is unknown. The objective of this study was to describe the germline mutations of LS in Caribbean Hispanics from Puerto Rico and Dominican Republic. A total of 89 subjects were recruited through...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25782445
DOI: 10.1007/s10689-015-9795-y
PMCID: PMC4560599

Genes

MLH1
MSH2
MSH6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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