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Article

Fast score test with global null estimation regardless of missing genotypes.

PloS one - 1 Jan 2018

Sato Shuntaro, Ueki Masao

Abstract excerpt

In genome-wide association studies (GWASs) for binary traits (or case-control samples) in the presence of covariates to be adjusted for, researchers often use a logistic regression model to test variants for disease association. Popular tests include Wald, likelihood ratio, and score tests. For likelihood ratio test and Wald test, maximum likelihood estimation (MLE), which requires iterative procedure, must be...

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Identifiers

PMID: 29975732
DOI: 10.1371/journal.pone.0199692
PMCID: PMC6033421

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